Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8kdb
Q-score: 0.577
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Human parainfluenza virus hpiv3 l-p polymerase in dimeric form (Complex from Human respirovirus 3)
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8kdc
Q-score: 0.506
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
- Human parainfluenza virus hpiv3 l-p polymerase in monomeric form (Complex from Human respirovirus 3)
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8tqi
Q-score: 0.499
Suryadevara N, Otrelo-Cardoso AR, Kose N, Hu YX, Binshtein E, Wolters R, Drew-Bear J, Handal LS, Carnahan RH, Moscona A, Jardetzky TS, Crowe Jr JE
To Be Published
- Hpiv3 hn in complex with rpiv3-23 and rpiv3-28 fabs (Complex from Human respirovirus 3)
- Light chain fab rpiv3-28 (23 kDa, Protein from Homo sapiens)
- Hemagglutinin-neuraminidase (50 kDa, Protein from Human respirovirus 3)
- Heavy chain fab rpiv3-28 (23 kDa, Protein from Homo sapiens)
- Heavy chain fab rpiv3-23 (24 kDa, Protein from Homo sapiens)
- Light chain fab rpiv3-23 (23 kDa, Protein from Homo sapiens)
- Recombinant rpiv3-23 fab (Complex from Homo sapiens)
- Recombinant rpiv3-28 fab (Complex from Homo sapiens)
- Hemagglutinin-neuraminidase glycoprotein (Complex from Human respirovirus 3)
Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tqk
Q-score: 0.451
Suryadevara N, Otrelo-Cardoso AR, Kose N, Hu YX, Binshtein E, Wolters R, Drew-Bear J, Handal LS, Carnahan RH, Moscona A, Jardetzky TS, Crowe Jr JE
To Be Published
- Fusion glycoprotein f0 (57 kDa, Protein from Human respirovirus 3)
- Fusion glycoprotein f0 (Complex from Human respirovirus 3)
- Rpiv3-18 heavy chain (Complex from Homo sapiens)
- Rpiv3-18 light chain (Complex from Homo sapiens)
- Hpiv3 prefusion f trimer in complex with rpiv3-18 fab (Complex from Human respirovirus 3)
- Heavy chain fab rpiv3-18 (23 kDa, Protein from Homo sapiens)
- Light chain fab rpiv3-28 (23 kDa, Protein from Homo sapiens)
Subtomogram average of the HN/F fusion complex on authentic viral surfaces of HPIV3
Marcink TC, Zipursky G, Cheng W, Stearns K, Stenglein S, Golub K, Cohen F, Bovier F, Pfalmer D, Greninger AL, Porotto M, des Georges A, Moscona A
Sci Adv (2023) 9 pp. eade2727-eade2727 [ Pubmed: 36763666 DOI: doi:10.1126/sciadv.ade2727 ]
Subtomogram average of the PIA174 Fab/F complex on authentic viral surfaces of HPIV3
Marcink TC, Zipursky G, Cheng W, Stearns K, Stenglein S, Golub K, Cohen F, Bovier F, Pfalmer D, Greninger AL, Porotto M, des Georges A, Moscona A
Sci Adv (2023) 9 pp. eade2727-eade2727 [ Pubmed: 36763666 DOI: doi:10.1126/sciadv.ade2727 ]
Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6mjz
Q-score: 0.282
Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, Thomas PV, Yang Y, Foulds KE, Todd JP, Wei H, Salazar AM, Scorpio DG, Carragher B, Potter CS, Corti D, Mascola JR, Lanzavecchia A, Kwong PD
PNAS (2018) 115 pp. 12265-12270 [ DOI: doi:10.1073/pnas.1811980115 Pubmed: 30420505 ]
- Pia174 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Complex of hpiv3 env q162c-l168c, i213c-g230c, a463v, i474y in complex with antibody pia174 (Complex from Human respirovirus 3)
- Fusion glycoprotein f0 (54 kDa, Protein from Human parainfluenza virus 3)
- Pia174 fab light chain (22 kDa, Protein from Homo sapiens)